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新的环氧呋喃型木脂素及来自毛叶琼楠叶的抗结核成分

Novel epoxyfuranoid lignans and antitubercular constituents from the leaves of Beilschmiedia tsangii.

作者信息

Chen Jih-Jung, Chou En-Tzu, Peng Chien-Fang, Chen Ih-Sheng, Yang Sheng-Zehn, Huang Hung-Yi

机构信息

Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan.

出版信息

Planta Med. 2007 Jun;73(6):567-71. doi: 10.1055/s-2007-967195. Epub 2007 May 22.

DOI:10.1055/s-2007-967195
PMID:17520523
Abstract

Three new epoxyfuranoid lignans, 4alpha,5alpha-epoxybeilschmin A (1), 4alpha,5alpha-epoxybeilschmin B (2), and beilschmin D (3), together with nine known compounds have been isolated from the leaves of Beilschmiedia tsangii. The structures of these new compounds were determined through spectral analyses. Among the isolates, beilschmin A (4) and beilschmin B (5) exhibited potent antitubercular activities (MICs = 2.5 and 7.5 microg/mL, respectively) against Mycobacterium tuberculosis 90 - 221387 in vitro.

摘要

从台湾琼楠的叶子中分离出了三种新的环氧呋喃型木脂素，即4α,5α-环氧琼楠素A（1）、4α,5α-环氧琼楠素B（2）和琼楠素D（3），以及九种已知化合物。通过光谱分析确定了这些新化合物的结构。在分离出的化合物中，琼楠素A（4）和琼楠素B（5）在体外对结核分枝杆菌90 - 221387表现出较强的抗结核活性（MIC分别为2.5和7.5微克/毫升）。

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