Departments of Medicine and Microbiology, University of New Mexico School of Medicine, Stanford and Lomas, Albuquerque, New Mexico 87131.
Infect Immun. 1974 Nov;10(5):1003-9. doi: 10.1128/iai.10.5.1003-1009.1974.
Sixty-one patients with a variety of different illnesses were studied with respect to skin test anergy and the presence of serum chemotactic inhibitors. In initial testing, 55% of the patient tests demonstrated negative skin test responses to all six test antigens. Sera from 65% of these anergic patients were capable of suppressing the migration of normal polymorphonuclear leukocytes toward chemotactic factors. Statistical analysis of the association of anergy and chemotactic inhibitory sera resulted in a P value of <0.0005. Chemotactic inhibitory sera were also capable of suppressing monocyte chemotaxis. No association of chemotactic inhibitory activity and lymphocytotoxic antibody or suppressors of mitogen-induced lymphocyte blast transformation were noted. In addition, T-cell populations in some anergic patients were studied by the erythrocyte-binding technique. Erythrocyte-binding lymphocytes in anergic patients were significantly suppressed when compared to normal controls, but not when compared to skin test-positive patients. The data presented here indicate a close parallel between skin test anergy and the presence of serum chemotactic inhibitory activity. The exact relationship is yet undefined but may indicate the involvement of chemotactic inhibitors as immunological regulators in the host during a variety of systemic illnesses.
对 61 名患有各种不同疾病的患者进行了皮肤试验无反应性和血清趋化抑制物存在的研究。在初始测试中，55%的患者试验对所有 6 种测试抗原均表现出阴性皮肤试验反应。这些无反应性患者中的 65%的血清能够抑制正常多形核白细胞向趋化因子的迁移。无反应性和趋化抑制性血清之间的关联的统计学分析导致 P 值 <0.0005。趋化抑制性血清也能够抑制单核细胞趋化性。未注意到趋化抑制活性与淋巴细胞毒性抗体或有丝分裂原诱导的淋巴细胞转化抑制剂之间存在关联。此外，还通过红细胞结合技术研究了一些无反应性患者的 T 细胞群体。与正常对照相比，无反应性患者的红细胞结合淋巴细胞受到明显抑制，但与皮肤试验阳性患者相比则不受抑制。这里提出的数据表明皮肤试验无反应性与血清趋化抑制活性的存在之间存在密切的平行关系。确切的关系尚不清楚，但可能表明趋化抑制剂作为免疫调节剂在宿主中参与各种全身性疾病。
