雄激素和雌激素对白色念珠菌延迟皮肤试验反应的影响。
Influence of Androgen and Estrogen on Delayed Skin Test Reactivity to Candida albicans.
机构信息
Departments of Microbiology and Medicine, Arizona Medical Center, University of Arizona, Tucson, Arizona 85724.
出版信息
Infect Immun. 1974 Nov;10(5):971-4. doi: 10.1128/iai.10.5.971-974.1974.
Recipient adult male CFW mice were passively sensitized to candida delayed skin test reactivity with splenic lymphoid cells from candida-vaccinated donor females. In recipient adult males that had been bilaterally gonadectomized as weanlings, before passive sensitization, reactivity was less than in the unilaterally gonadectomized controls. Adult males bilaterally gonadectomized as weanlings were treated with gonadal hormones during passive sensitization. 17beta-estradiol was found to decrease reactivity, whereas testosterone was found to increase reactivity. These data provide evidence that delayed skin test reactivity produced by female lymphoid cells is depressed by estrogen and is stimulated by androgen.
受者成年雄性 CFW 小鼠通过来自于接种了念珠菌的供体雌性的脾淋巴细胞被动致敏念珠菌延迟皮肤试验反应。在接受者成年雄性中，双侧去势于断乳时，在被动致敏之前，其反应性小于单侧去势的对照。在被动致敏期间，双侧去势的成年雄性用性腺激素治疗。发现 17β-雌二醇降低反应性，而睾酮发现增加反应性。这些数据提供了证据表明，由雌性淋巴细胞产生的延迟皮肤试验反应受到雌激素的抑制，而受到雄激素的刺激。
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