Isoda M
Mycopathologia. 1985 Sep;91(3):187-92. doi: 10.1007/BF00446299.
Guinea pigs immunized intramuscularly with heat-killed or viable Candida albicans were infected intracutaneously with C. albicans. Animals with negative delayed hypersensitivity against C. albicans antigen showed similar lesions with non-immunized controls. Delayed hypersensitivity-positive guinea pigs, which were detected in the animals immunized with heat-killed C. albicans in CFA and IFA, demonstrated a delay of the resolution of the inflammatory tissue reaction and, in the animals immunized with C. albicans in CFA, developed a granuloma. These results suggest that both humoral and cell-mediated immunities do not play a significant role for protection against candidiasis and at a late stage of infection, cell-mediated immunity may play a secondary role of the enhancement of resistance to candida infection associated with granuloma formation.
用热灭活或活的白色念珠菌进行肌肉注射免疫的豚鼠，再经皮内注射白色念珠菌进行感染。对白色念珠菌抗原迟发型超敏反应阴性的动物，其病变与未免疫的对照相似。在用热灭活的白色念珠菌于弗氏完全佐剂（CFA）和弗氏不完全佐剂（IFA）中免疫的动物中检测到的迟发型超敏反应阳性的豚鼠，表现出炎症组织反应消退延迟，而在用白色念珠菌于CFA中免疫的动物中则形成了肉芽肿。这些结果表明，体液免疫和细胞介导免疫在抗念珠菌病保护中均未发挥重要作用，且在感染后期，细胞介导免疫可能在与肉芽肿形成相关的增强对念珠菌感染的抵抗力方面发挥次要作用。
