CFW小鼠对白色念珠菌抗体反应的性别差异。
Sex difference in antibody response of CFW mice to Candida albicans.
作者信息
Rifkind D, Frey J A
出版信息
Infect Immun. 1972 May;5(5):695-8. doi: 10.1128/iai.5.5.695-698.1972.
Abstract
Bilaterally gonadectomized and control unilaterally gonadectomized male and female CFW mice were given a course of Candida albicans vaccine, and the agglutinating antibody response was measured. The mean titers in the control females were higher than those in the control males. Bilateral gonadectomy did not affect the mean titer in the females but in the males resulted in a significant increase in the antibody. Similar groups of mice were inoculated intraperitoneally with viable C. albicans, and 10 weeks later antibody was measured and the kidneys were cultured. There was no apparent relationship between the degree of the agglutinin response and either gonadectomy or renal candidiasis at autopsy.
摘要
对双侧去势和单侧去势的雄性和雌性CFW对照小鼠接种白色念珠菌疫苗，并检测其凝集抗体反应。对照雌性小鼠的平均滴度高于对照雄性小鼠。双侧去势对雌性小鼠的平均滴度没有影响，但对雄性小鼠而言，却导致抗体显著增加。用活的白色念珠菌对相似的小鼠组进行腹腔接种，10周后检测抗体并培养肾脏。尸检时，凝集素反应程度与去势或肾念珠菌病之间没有明显关系。
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