大肠杆菌中己糖磷酸转运的遗传控制：uhp 基因座的定位
Genetic Control of the Transport of Hexose Phosphates in Escherichia coli: Mapping of the uhp Locus.
作者信息
Kadner R J
机构信息
Department of Microbiology, University of Virginia School of Medicine, Charlottesville, Virginia 22903.
出版信息
J Bacteriol. 1973 Nov;116(2):764-70. doi: 10.1128/jb.116.2.764-770.1973.
Abstract
A number of mutations affecting the transport of hexose phosphates in Escherichia coli were ordered within the uhp locus. Three-point crosses by transduction or conjugation allowed the ordering of the alleles relative to the adjacent pyrE marker. The same linear map was obtained by both methods. This, combined with the regulatory properties of revertants of these mutants, allowed a tentative identification of two genes, one presumably coding for the transport system (uhpT) and the other(s) specifying a regulatory element (uhpR). The order of these is pyrE-uhpT-uhpR. Mutants exhibiting constitutive expression of the transport system were isolated. This behavior is genetically linked to the uhp locus, but more precise localization was not possible.
摘要
一些影响大肠杆菌中己糖磷酸转运的突变在uhp基因座内排列。通过转导或接合进行的三点杂交确定了这些等位基因相对于相邻pyrE标记的顺序。两种方法得到了相同的线性图谱。这一点，再结合这些突变体回复子的调控特性，使得我们初步鉴定出两个基因，一个可能编码转运系统（uhpT），另一个（些）则指定一个调控元件（uhpR）。它们的顺序是pyrE-uhpT-uhpR。分离出了表现出转运系统组成型表达的突变体。这种行为在遗传上与uhp基因座相关，但无法进行更精确的定位。
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