影响大肠杆菌中己糖磷酸转运的突变的分离与鉴定
Isolation and characterization of mutations affecting the transport of hexose phosphates in Escherichia coli.
作者信息
Kadner R J, Winkler H H
出版信息
J Bacteriol. 1973 Feb;113(2):895-900. doi: 10.1128/jb.113.2.895-900.1973.
Abstract
Mutants of Escherichia coli defective in the hexose phosphate transport system were isolated. Negative selection by penicillin treatment or positive selection with phosphonomycin was employed. These mutants grew normally on all carbon sources other than hexose phosphates. The map location of the mutations in 18 independently isolated mutant strains was investigated by transduction crosses. All of the mutations were found to lie in the same region of the chromosome, in the region represented by min 72 on the Taylor map. The order of the genes in this region was found to be mtl-cysE-pyrE-uhp-bgl-ilv. Revertants of some of the mutants exhibited altered regulatory control of this transport system.
摘要
分离出了磷酸己糖转运系统存在缺陷的大肠杆菌突变体。采用青霉素处理进行负向选择或用磷霉素进行正向选择。这些突变体在除磷酸己糖以外的所有碳源上都能正常生长。通过转导杂交研究了18个独立分离的突变菌株中突变的图谱位置。发现所有突变都位于染色体的同一区域，即在泰勒图谱上由72分钟表示的区域。发现该区域基因的顺序为mtl-cysE-pyrE-uhp-bgl-ilv。一些突变体的回复突变体表现出该转运系统调控控制的改变。
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