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莱姆病疏螺旋体的动态蛋白质组

The dynamic proteome of Lyme disease Borrelia.

作者信息

Norris Steven J

机构信息

Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston, TX 77225-0708, USA.

出版信息

Genome Biol. 2006;7(3):209. doi: 10.1186/gb-2006-7-3-209. Epub 2006 Mar 17.

DOI:10.1186/gb-2006-7-3-209
PMID:16563176
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1557748/
Abstract

The proteome of the spirochete bacterium Borrelia burgdorferi, the tick-borne agent of Lyme disease, has been characterized by two different approaches using mass spectrometry, providing a launching point for future studies on the dramatic changes in protein expression that occur during transmission of the bacterium between ticks and mammals.

摘要

莱姆病的蜱传病原体——螺旋体伯氏疏螺旋体的蛋白质组，已通过两种不同的质谱分析方法进行了表征，这为未来研究该细菌在蜱和哺乳动物之间传播过程中发生的蛋白质表达的显著变化提供了一个起点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/901cc35f5397/gb-2006-7-3-209-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/8b54d8683442/gb-2006-7-3-209-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/67a5a7cb9900/gb-2006-7-3-209-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/901cc35f5397/gb-2006-7-3-209-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/8b54d8683442/gb-2006-7-3-209-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/67a5a7cb9900/gb-2006-7-3-209-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28a9/1557748/901cc35f5397/gb-2006-7-3-209-3.jpg

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Proteomics. 2006 Apr;6(7):2121-34. doi: 10.1002/pmic.200500187.
2
Global whole-cell FTICR mass spectrometric proteomics analysis of the heat shock response in the radioresistant bacterium Deinococcus radiodurans.耐辐射细菌耐辐射球菌热休克反应的全细胞傅里叶变换离子回旋共振质谱蛋白质组学全球分析。
J Proteome Res. 2005 May-Jun;4(3):709-18. doi: 10.1021/pr049815n.
3
The development of the DIGE system: 2D fluorescence difference gel analysis technology.
明确新西兰白兔体内高保护性抗体针对的莱姆病病原体表面抗原表位。
Infect Immun. 2019 Jul 23;87(8). doi: 10.1128/IAI.00246-19. Print 2019 Aug.
4
New Zealand White Rabbits Effectively Clear Borrelia burgdorferi B31 despite the Bacterium's Functional Antigenic Variation System.新西兰白兔可有效清除博尔纳病螺旋体 B31，尽管该细菌具有功能抗原变异系统。
Infect Immun. 2019 Jun 20;87(7). doi: 10.1128/IAI.00164-19. Print 2019 Jul.
5
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Cell Microbiol. 2019 Feb;21(2):e12885. doi: 10.1111/cmi.12885. Epub 2018 Jul 8.
6
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9
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Infect Immun. 2008 Nov;76(11):5274-84. doi: 10.1128/IAI.00803-08. Epub 2008 Sep 2.
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4
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7
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Infect Immun. 2004 Sep;72(9):5419-32. doi: 10.1128/IAI.72.9.5419-5432.2004.
8
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Infect Immun. 2003 Jun;71(6):3419-28. doi: 10.1128/IAI.71.6.3419-3428.2003.
9
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Infect Immun. 2003 Apr;71(4):1689-705. doi: 10.1128/IAI.71.4.1689-1705.2003.
10
The use of accurate mass tags for high-throughput microbial proteomics.用于高通量微生物蛋白质组学的精确质量标签的应用
OMICS. 2002;6(1):61-90. doi: 10.1089/15362310252780843.