Isolation and characterization of herpes simplex virus resistant to nucleoside analogs.
作者信息
Katz E, Rosenblat O, Pisanty S
机构信息
Department of Virology, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
出版信息
Oral Surg Oral Med Oral Pathol. 1991 Sep;72(3):296-9. doi: 10.1016/0030-4220(91)90218-2.
Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in BSC1 cells in the presence of 5-iodo-2'-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2'-deoxyuridine and acyclovir and failed to induce significant activity of thymidine kinase in cultures. Herpesvirus reisolated from the same patient 3 1/2 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.
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