McMahon Stephen B, Wood John N
London Pain Consortium, King's College London, London WC2R 2LS, United Kingdom.
Cell. 2006 Mar 24;124(6):1123-5. doi: 10.1016/j.cell.2006.03.006.
TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.
瞬时受体电位（TRP）阳离子通道可传导机械、热和疼痛相关的炎症信号。在本期《细胞》杂志中，有报道称TRPA1在内源性炎症介质以及多种挥发性刺激物（包括催泪瓦斯和大蒜中的刺激物）引起的疼痛反应中起核心作用。相比之下，TRPA1基因敲除小鼠的机械感觉和温度感觉正常。
