Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucureșt, Romania.
Int J Mol Sci. 2024 Jun 19;25(12):6753. doi: 10.3390/ijms25126753.
Wound healing involves physical, chemical and immunological processes. Transient receptor potential (TRP) and other ion channels are implicated in epidermal re-epithelization. Ion movement across ion channels can induce transmembrane potential that leads to transepithelial potential (TEP) changes. TEP is present in epidermis surrounding the lesion decreases and induces an endogenous direct current generating an epithelial electric field (EF) that could be implicated in wound re-epithelialization. TRP channels are involved in the activation of immune cells during mainly the inflammatory phase of wound healing. The aim of the study was to review the mechanisms of ion channel involvement in wound healing in in vivo experiments in murine (mice, rats) and how can this process be influenced. This review used the latest results published in scientific journals over the last year and this year to date (1 January 2023-31 December 3000) in order to include the in-press articles. Some types of TRP channels, such as TRPV1, TRPV3 and TRPA1, are expressed in immune cells and can be activated by inflammatory mediators. The most beneficial effects in wound healing are produced using agonists of TRPV1, TRPV4 and TRPA1 channels or by inhibiting with antagonists, antisense oligonucleotides or knocking down TRPV3 and TRPM8 channels.
伤口愈合涉及物理、化学和免疫学过程。瞬时受体电位 (TRP) 和其他离子通道与表皮再上皮化有关。离子通过离子通道的运动可以诱导跨膜电位，从而导致跨上皮电位 (TEP) 变化。病变周围表皮中的 TEP 减少，并诱导内源性直流产生上皮电场 (EF)，这可能与伤口再上皮化有关。TRP 通道参与免疫细胞的激活，主要发生在伤口愈合的炎症阶段。本研究旨在综述离子通道在体内实验（鼠类、大鼠）中参与伤口愈合的机制，以及如何影响这一过程。本综述使用了过去一年和今年截至 2023 年 1 月 1 日至 31 日（3000 年）的科学期刊上发表的最新研究结果，以纳入即将出版的文章。某些类型的 TRP 通道，如 TRPV1、TRPV3 和 TRPA1，在免疫细胞中表达，并可被炎症介质激活。使用 TRPV1、TRPV4 和 TRPA1 通道的激动剂或通过拮抗剂、反义寡核苷酸或敲低 TRPV3 和 TRPM8 通道进行抑制，可以产生最有益的伤口愈合效果。
