Lukowiak Ken, Martens Kara, Orr Mike, Parvez Kashif, Rosenegger David, Sangha Susan
Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
Respir Physiol Neurobiol. 2006 Nov;154(1-2):61-72. doi: 10.1016/j.resp.2006.02.009. Epub 2006 Mar 6.
Aerial respiratory in Lymnaea is driven by a three-neuron CPG whose sufficiency and necessity has been directly demonstrated. While this CPG is 'hard-wired' it displays a tremendous amount of plasticity. That is, it is possible by employing specific training procedures to alter how it functions in a specific hypoxic environment. Thus, it is possible to study directly the causal mechanisms of long-term memory formation, forgetting, and modulation of the memory at a single cell level. Thus, it is possible to use a relatively simple three-neuron CPG to study not only important questions concerning regulation of important homeostatic mechanisms but to also use it to study how learning and non-declarative memory are mediated at a cellular level.
椎实螺的空中呼吸由一个三神经元中枢模式发生器驱动，其充分性和必要性已得到直接证明。虽然这个中枢模式发生器是“硬连线”的，但它表现出极大的可塑性。也就是说，通过采用特定的训练程序，可以改变它在特定缺氧环境中的功能方式。因此，有可能在单细胞水平上直接研究长期记忆形成、遗忘和记忆调节的因果机制。因此，有可能使用一个相对简单的三神经元中枢模式发生器，不仅研究有关重要稳态机制调节的重要问题，还利用它来研究学习和非陈述性记忆在细胞水平上是如何介导的。
