一名接受英夫利昔单抗治疗强直性脊柱炎的患者发生眼眶蜂窝织炎。
Orbital cellulitis in a patient receiving infliximab for Ankylosing spondylitis.
作者信息
Roos Jonathan C P, Ostor Andrew J K
机构信息
Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
出版信息
Am J Ophthalmol. 2006 Apr;141(4):767-9. doi: 10.1016/j.ajo.2005.11.017.
PURPOSE
To describe a case of orbital cellulitis arising in a patient treated with an anti-TNFalpha agent.
DESIGN
Single interventional case report.
METHODS
A 42-year-old man developed severe unilateral orbital cellulitis while receiving infliximab (Remicade, Centocor) treatment for Ankylosing spondylitis (AS) as part of the open-label phase of a trial conducted at our tertiary referral center. Cultures grew Staphylococcus aureus.
RESULTS
Infliximab treatment was stopped and the patient made a full recovery after receiving appropriate antibiotic therapy. Infliximab therapy was resumed after three weeks.
CONCLUSIONS
Clinical vigilance is warranted when treating patients with anti-TNFalpha agents as these are associated with a diverse and growing number of ophthalmic complications. Resolved infection does not preclude the use of such agents.
目的
描述1例接受抗TNFα药物治疗的患者发生眼眶蜂窝织炎的病例。
设计
单例介入病例报告。
方法
一名42岁男性在接受英夫利昔单抗（类克，Centocor公司）治疗强直性脊柱炎（AS）时发生严重单侧眼眶蜂窝织炎，该治疗是在我们三级转诊中心进行的一项试验开放标签阶段的一部分。培养结果显示为金黄色葡萄球菌。
结果
停用英夫利昔单抗治疗，患者在接受适当抗生素治疗后完全康复。三周后恢复英夫利昔单抗治疗。
结论
在使用抗TNFα药物治疗患者时应保持临床警惕，因为这些药物与越来越多的眼科并发症相关。已解决的感染并不排除使用此类药物。
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