巨大椎旁脓肿作为克罗恩病英夫利昔单抗治疗的一种并发症。
Large paraspinal abscess as a complication of infliximab therapy in Crohn's disease.
作者信息
Nithianandan Nishani, Loftus Michael J, Johnson Paul D R, Charles Patrick G P
机构信息
Department of General Medicine, Austin Health, Heidelberg, Victoria, Australia.
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.
出版信息
BMJ Case Rep. 2019 Apr 29;12(4):e227665. doi: 10.1136/bcr-2018-227665.
Abstract
We report a 36-year-old man who developed a large epidural and paraspinal abscess as a complication of infliximab therapy being used for underlying Crohn's disease. Cultures of the collection grew methicillin-susceptible , and treatment consisted of abscess drainage, prolonged intravenous and oral flucloxacillin and temporary withholding of his infliximab. While infection-related complications are well described with infliximab therapy, this is the first description of a large paraspinal abscess with epidural extension.
摘要
我们报告一名36岁男性，其因潜在的克罗恩病接受英夫利昔单抗治疗而发生了巨大的硬膜外和椎旁脓肿并发症。采集物培养出对甲氧西林敏感的细菌，治疗包括脓肿引流、长期静脉及口服氟氯西林，以及暂时停用英夫利昔单抗。虽然英夫利昔单抗治疗相关的感染并发症已有详尽描述，但这是首次描述巨大的伴有硬膜外扩展的椎旁脓肿。
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本文引用的文献
1
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Soluble immune effector molecules [I]: anti-tumor necrosis factor-α agents).ESCMID 研究组对免疫受损宿主感染（ESGICH）共识文件：靶向和生物治疗的安全性：传染病观点（可溶性免疫效应分子 [I]：抗肿瘤坏死因子-α制剂）
Clin Microbiol Infect. 2018 Jun;24 Suppl 2:S10-S20. doi: 10.1016/j.cmi.2017.12.025. Epub 2018 Feb 6.
2
Spinal Epidural Abscess: A Series of 101 Cases.脊柱硬膜外脓肿：101例病例系列
Am J Med. 2017 Dec;130(12):1458-1463. doi: 10.1016/j.amjmed.2017.07.017. Epub 2017 Aug 7.
3
Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis.生物疗法与炎症性肠病患者感染和恶性肿瘤风险：系统评价和网络荟萃分析。
Clin Gastroenterol Hepatol. 2016 Oct;14(10):1385-1397.e10. doi: 10.1016/j.cgh.2016.04.039. Epub 2016 May 14.
4
Alterations in immune function with biologic therapies for autoimmune disease.生物疗法治疗自身免疫性疾病时免疫功能的改变。
J Allergy Clin Immunol. 2016 Jan;137(1):19-27. doi: 10.1016/j.jaci.2015.10.023.
5
Risk of serious infection in biological treatment of patients with rheumatoid arthritis: a systematic review and meta-analysis.类风湿关节炎患者生物治疗中严重感染的风险：一项系统评价和荟萃分析。
Lancet. 2015 Jul 18;386(9990):258-65. doi: 10.1016/S0140-6736(14)61704-9. Epub 2015 May 11.
6
Spinal epidural abscesses: risk factors, medical versus surgical management, a retrospective review of 128 cases.脊髓硬膜外脓肿：危险因素、内科与外科治疗，128 例回顾性研究。
Spine J. 2014 Feb 1;14(2):326-30. doi: 10.1016/j.spinee.2013.10.046. Epub 2013 Nov 12.
7
Chest pain as presenting symptom of Staphyloccocus aureus epidural abscess associated with anti-tumor necrosis factor and methotrexate therapy.胸疼为肿瘤坏死因子拮抗剂和甲氨蝶呤治疗相关的金黄色葡萄球菌硬脊膜外脓肿的首发症状。
J Clin Rheumatol. 2009 Dec;15(8):396-8. doi: 10.1097/RHU.0b013e3181c3f8bf.
8
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J Neurosurg Spine. 2008 Sep;9(3):261-4. doi: 10.3171/SPI/2008/9/9/261.
9
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Clin Immunol. 2008 Jan;126(1):13-30. doi: 10.1016/j.clim.2007.08.012. Epub 2007 Oct 4.
10
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N Engl J Med. 2006 Nov 9;355(19):2012-20. doi: 10.1056/NEJMra055111.
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