Ahmadi-Hamedani Mahmood, Mirmohammadkhani Majid, Kafshdouzan Khatereh, Amoozadeh Parsa, Heydarkhani Yeganeh
Department of Clinical Sciences, Faculty of Veterinary Medicine, Semnan University, Semnan, Iran.
Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.
J Vet Intern Med. 2025 Sep-Oct;39(5):e70239. doi: 10.1111/jvim.70239.
Iron-limited erythropoiesis (ILE) is a common condition in dogs and cats, which can lead to anemia; therefore, monitoring with erythrocyte and reticulocyte indices is recommended.
To compare the values of mean corpuscular volume (MCV), mean reticulocyte volume (MCVr), and reticulocyte hemoglobin content (CHr) in dogs and cats with ILE.
Systemative review and meta-analysis. We conducted a systematic search using PRISMA criteria in PubMed, ScienceDirect, and Google Scholar up to 2024. It focused on erythrocyte and reticulocyte indices, such as MCV, MCVr, and CHr, in dogs and cats with ILE.
This meta-analysis included eight articles. For dogs, the random effect sizes were 2.86 (0.55-5.18) for MCV, 2.18 (0.87-3.58) for MCVr, and 4.73 (1.37-8.08) for CHr. For cats, the effect sizes were 0.85 (0.19-1.5) for MCV, 3.45 (0.49-6.41) for MCVr, and 2.51 (0.29-4.74) for CHr. The analysis revealed I values of 97%, 94.3%, and 98.2% in dogs, and 63.1%, 93%, and 95.1% in cats, for MCV, MCVr, and CHr, respectively. The overall random effects were 1.98 for MCV, 2.54 for MCVr, and 3.87 for CHr.
The findings revealed significant differences in reticulocyte indices, MCVr in cats, and CHr in dogs between the ILE-affected and the healthy groups. Considerable variability among studies indicates caution in generalizing findings and makes conclusions less definitive.
铁限制红细胞生成（ILE）在犬猫中是一种常见病症，可导致贫血；因此，建议通过红细胞和网织红细胞指标进行监测。
比较患有ILE的犬猫的平均红细胞体积（MCV）、平均网织红细胞体积（MCVr）和网织红细胞血红蛋白含量（CHr）的值。
系统评价和荟萃分析。我们按照PRISMA标准在PubMed、ScienceDirect和谷歌学术上进行了系统检索，截至2024年。重点关注患有ILE的犬猫的红细胞和网织红细胞指标，如MCV、MCVr和CHr。
该荟萃分析纳入了8篇文章。对于犬，MCV的随机效应大小为2.86（0.55 - 5.18），MCVr为2.18（0.87 - 3.58），CHr为4.73（1.37 - 8.08）。对于猫，MCV的效应大小为0.85（0.19 - 1.5），MCVr为3.45（0.49 - 6.41），CHr为2.51（0.29 - 4.74）。分析显示，犬的MCV、MCVr和CHr的I值分别为97%、94.3%和98.2%，猫的分别为63.1%、93%和95.1%。MCV的总体随机效应为1.98，MCVr为2.54，CHr为3.87。
研究结果显示，在受ILE影响的组和健康组之间，网织红细胞指标存在显著差异，猫的MCVr和犬的CHr有差异。研究之间存在相当大的变异性，这表明在推广研究结果时要谨慎，结论也不那么确定。
