Hayat Sawsan J, Uppal Sukhbir S, Narayanan Nampoory M R, Johny Kaivilayil V, Gupta Ramkumar, Al-Oun Mohammed
Department of Medicine, Kuwait University and Mubarak Al-Kabeer Hospital, Kuwait.
Clin Rheumatol. 2007 Jun;26(6):973-5. doi: 10.1007/s10067-006-0219-0. Epub 2006 Mar 25.
Because disease activity in systemic lupus erythematosus correlates well with increased serum levels and activity of the cytokine tumor necrosis factor alpha (TNF-alpha), we report on the safety and efficacy of infliximab, a chimeric monoclonal antibody directed against TNF-alpha, given to a patient with active lupus with diffuse proliferative nephritis (WHO Class IV). This patient who failed to remit with a combination of full-dose steroids, mycophenolate mofetil, and cyclosporine, went into sustained remission with the addition of infliximab infusions.
由于系统性红斑狼疮的疾病活动与细胞因子肿瘤坏死因子α（TNF-α）的血清水平升高及活性密切相关，我们报告了英夫利昔单抗（一种针对TNF-α的嵌合单克隆抗体）用于一名患有活动性狼疮伴弥漫性增殖性肾炎（世界卫生组织IV级）患者的安全性和有效性。该患者在使用大剂量类固醇、霉酚酸酯和环孢素联合治疗后未能缓解，在加用英夫利昔单抗输注后实现了持续缓解。
