Waszczykowska E, Robak E, Wozniacka A, Narbutt J, Torzecka J D, Sysa-Jedrzejowska A
Department of Dermatology and Venereology, Medical University of Lodz, Poland.
Mediators Inflamm. 1999;8(2):93-100. doi: 10.1080/09629359990586.
We estimated the serum levels of IL-6, TNF-alpha and IL-10, and generation of superoxide radicals, as well as their mutual dependence, in 63 SLE patients at various stages of disease activity. Our results indicate a statistically significant increase of the serum levels studied, and an increase of superoxide anion generation by granulocytes, in correlation with SLE activity. These results indicate that oxygen metabolism and the examined cytokines play an important role in pathogenesis of SLE. The assessment of these parameters can be useful in the estimation of disease activity.
我们评估了63例处于疾病活动不同阶段的系统性红斑狼疮(SLE)患者的血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和白细胞介素-10(IL-10)水平、超氧自由基的生成情况及其相互依赖性。我们的结果表明,所研究的血清水平在统计学上显著升高,并且粒细胞产生超氧阴离子增加,这与SLE活动相关。这些结果表明,氧代谢和所检测的细胞因子在SLE发病机制中起重要作用。对这些参数的评估有助于估计疾病活动度。