Nuovo J
Department of Family Medicine, University of Washington, Seattle.
J Am Board Fam Pract. 1991 Jul-Aug;4(4):229-36.
Oat products have become popular as a treatment for hypercholesterolemia. This article was designed to address the following question: Do existing data support the conclusion that oat products are effective cholesterol-lowering agents? A comprehensive search found 11 eligible reports. Each report was analyzed for baseline data, research methodology, and study results. A quality score was assigned to each report. Nine of the 11 eligible reports scored 4 points or less (maximum possible score was 10). Specific design concerns included lack of comparison control groups, failure to randomize and blind subjects to treatment assignment, failure to control for important confounding variables, such as impact of dietary changes known to affect serum cholesterol levels, and inadequate time allotment for cholesterol level stabilization. In most reports, a wide response to oat products was noted. Ninety-five percent confidence levels for cholesterol change ranged from -47.0 percent to +23.8 percent. Despite widespread approval, available reports do not provide evidence to support or reject the purported beneficial effect of oat products in the treatment of hypercholesterolemia.
燕麦产品已成为治疗高胆固醇血症的常用方法。本文旨在探讨以下问题：现有数据是否支持燕麦产品是有效的降胆固醇药物这一结论？全面检索后找到11篇符合条件的报告。对每篇报告的基线数据、研究方法和研究结果进行了分析，并为每篇报告赋予了质量评分。11篇符合条件的报告中有9篇得分在4分及以下（满分10分）。具体的设计问题包括缺乏对照对照组、未对受试者进行随机分组和治疗分配设盲、未控制重要的混杂变量，如已知会影响血清胆固醇水平的饮食变化的影响，以及胆固醇水平稳定所需的时间分配不足。在大多数报告中，都注意到对燕麦产品的反应范围很广。胆固醇变化的95%置信区间为-47.0%至+23.8%。尽管获得广泛认可，但现有报告并未提供证据支持或反驳燕麦产品在治疗高胆固醇血症方面的所谓有益效果。
