Coppens T, Van den Bergh P, Duprez T J, Jeanjean A, De Ridder F, Sindic C J M
Service de Neurologie, Cliniques Universitaires Saint-Luc, Bruxelles, Belgique.
Eur Neurol. 2006;55(2):80-3. doi: 10.1159/000092307. Epub 2006 Mar 24.
Amphiphysin, a synaptic vesicle protein, is an auto-immune target in rare cases of paraneoplastic neurological disorders. We report two additional cases with distinct neurological syndromes and paraneoplastic anti-amphiphysin antibodies. The first patient, a 59-year-old man, presented with cerebellar and cranial nerve dysfunction and small cell lung carcinoma. The second, a 77-year- old woman, presented with left brachial plexopathy followed by sensorimotor neuropathy and breast carcinoma.
发动蛋白，一种突触小泡蛋白，在罕见的副肿瘤性神经系统疾病病例中是自身免疫靶点。我们报告另外两例具有不同神经系统综合征和副肿瘤性抗发动蛋白抗体的病例。首例患者为一名59岁男性，表现为小脑和颅神经功能障碍以及小细胞肺癌。第二例是一名77岁女性，表现为左臂丛神经病变，随后出现感觉运动性神经病变以及乳腺癌。
