Augsburger James J, Henson Ginger L, Hershberger Vrinda S, Trichopoulos Nikolaos
Department of Ophthalmology, University of Cincinnati College of Medicine, 3223 Eden Avenue, Suite 350, Cincinnati, OH 45267-0527, USA.
Graefes Arch Clin Exp Ophthalmol. 2006 Nov;244(11):1412-4. doi: 10.1007/s00417-006-0305-7. Epub 2006 Mar 28.
To describe the topographical distribution of typical congenital hypertrophy of retinal pigment epithelium (CHRPE) lesions in the ocular fundi.
Retrospective review of the clinical records of 52 patients with typical unifocal CHRPE.
The 52 CHRPE lesions ranged from 2.5 mm to 11.5 mm in maximal basal diameter (mean=6.6 mm, SD=2.6 mm). The central point of the lesion was in the peripheral fundus in 44 eyes and in the intermediate fundus in eight eyes. The footprint of the lesion involved the peripheral fundus only in 25 eyes, both the intermediate and peripheral fundus in 22 eyes, and the intermediate fundus only in five eyes. The central point of the lesion was located in the temporal quadrant in 24 eyes, the inferior quadrant in 12 eyes, the nasal quadrant in nine eyes, and the superior quadrant in seven eyes. No lesion in this series involved the posterior fundus.
The most common fundus location for typical unifocal CHRPE in this series was the peripheral fundus temporally. Although posterior fundus location of CHRPE has been reported occasionally, our study suggests that such a location is very uncommon.
描述典型视网膜色素上皮先天性肥大（CHRPE）病变在眼底的地形分布。
回顾性分析52例典型单灶性CHRPE患者的临床记录。
52处CHRPE病变的最大基底直径为2.5毫米至11.5毫米（平均=6.6毫米，标准差=2.6毫米）。病变中心点位于周边眼底的有44只眼，位于中间眼底的有8只眼。病变覆盖范围仅累及周边眼底的有25只眼，累及中间和周边眼底的有22只眼，仅累及中间眼底的有5只眼。病变中心点位于颞侧象限的有24只眼，位于下方象限的有12只眼，位于鼻侧象限的有9只眼，位于上方象限的有7只眼。本系列中无病变累及后极部眼底。
本系列中典型单灶性CHRPE最常见的眼底位置是颞侧周边眼底。虽然偶尔有CHRPE位于后极部眼底的报道，但我们的研究表明这种位置非常罕见。
