Purcell J J, Shields J A
Arch Ophthalmol. 1975 Nov;93(11):1122-6. doi: 10.1001/archopht.1975.01010020840002.
Fifty-two patients (one bilateral) exhibiting hypertrophy with hyperpigmentation of the retinal pigment epithelium (RPE) are described. Visual acuity was not affected, and the patients were asymptomatic. There was no correlation with systemic diseases, family history of eye disease, associated fundus lesions, anterior segment abnormalities, or intraocular pressure. Field defects were rarely demonstrated using standard clinical techniques. There were three characteristic locations and four characteristic pigmentary variations that occurred alone or in any combination. The lesions were gray, black, or brown. The clinical characteristics and histopathology suggest that hypertrophy with hyperpigmentation of the RPE and congenital grouped pigmentation are different expressions of a similar condition, with the former being focal and the latter multifocal.
本文描述了52例（其中1例为双眼）视网膜色素上皮（RPE）肥大伴色素沉着的患者。视力未受影响，患者也没有症状。这些患者与全身疾病、眼部疾病家族史、相关的眼底病变、眼前节异常或眼压均无关联。使用标准临床技术很少能发现视野缺损。病变有三个特征性位置和四种特征性色素变化，这些变化可单独出现或任意组合出现。病变颜色为灰色、黑色或棕色。临床特征和组织病理学表明，RPE肥大伴色素沉着和先天性成簇色素沉着是同一病症的不同表现形式，前者为局灶性，后者为多灶性。
