Chamot L, Zografos L, Klainguti G
University Eye Clinic, Lausanne, Switzerland.
Am J Ophthalmol. 1993 Feb 15;115(2):154-61. doi: 10.1016/s0002-9394(14)73918-2.
The clinical characteristics and follow-up changes of 64 patients with solitary congenital hypertrophy of the retinal pigment epithelium were studied. Thirty-five of the patients were followed up for one to 14 years with serial fundus photography. Progressive increase of the hypopigmented part of the lesion was observed in 29 of the 35 patients who were followed up (82.8%). An enlargement of the lesion was seen in 26 of the 35 patients (74.3%). Two additional changes, that is, pigmented areas adjacent to congenital hypertrophy of the retinal pigment epithelium and linear streaks of the pigment epithelium, were documented. Pathogenetic mechanisms for the development of these changes remain unknown.
对64例孤立性先天性视网膜色素上皮肥大患者的临床特征及随访变化进行了研究。35例患者接受了连续眼底照相随访，随访时间为1至14年。在接受随访的35例患者中，有29例（82.8%）观察到病变色素减退部分逐渐增加。35例患者中有26例（74.3%）病变出现扩大。还记录到另外两种变化，即先天性视网膜色素上皮肥大相邻的色素沉着区和色素上皮的线状条纹。这些变化发生的发病机制尚不清楚。
