一种合成内过氧化物（RBx-11160/OZ277）对加蓬恶性疟原虫分离株的抗疟活性。
Antimalarial activity of a synthetic endoperoxide (RBx-11160/OZ277) against Plasmodium falciparum isolates from Gabon.
作者信息
Kreidenweiss Andrea, Mordmüller Benjamin, Krishna Sanjeev, Kremsner Peter G
机构信息
Medical Research Laboratory, Albert Schweitzer Hospital, Lambaréné, Gabon, and Department of Parasitology, University of Tübingen, Wilhelmstr. 27, D-72074 Tübingen, Germany.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1535-7. doi: 10.1128/AAC.50.4.1535-1537.2006.
Abstract
OZ277 is a newly developed, fully synthetic endoperoxide antimalarial that we tested against field isolates from Gabon. A comparison of activities of OZ277 with artesunate, mefloquine, and chloroquine showed OZ277 to be highly active against all parasite isolates. Artesunate and mefloquine also showed potent antiparasitic activity, but all isolates were chloroquine resistant.
摘要
OZ277是一种新开发的全合成内过氧化物抗疟药，我们用它对加蓬的野外分离株进行了测试。将OZ277与青蒿琥酯、甲氟喹和氯喹的活性进行比较，结果显示OZ277对所有寄生虫分离株都具有高活性。青蒿琥酯和甲氟喹也显示出强大的抗寄生虫活性，但所有分离株都对氯喹耐药。
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