青蒿素和OZ277（RBx11160）的过氧化物键依赖性抗疟原虫特异性。
Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).
作者信息
Kaiser Marcel, Wittlin Sergio, Nehrbass-Stuedli Angela, Dong Yuxiang, Wang Xiaofang, Hemphill Andrew, Matile Hugues, Brun Reto, Vennerstrom Jonathan L
机构信息
Swiss Tropical Institute, Basel, Switzerland.
出版信息
Antimicrob Agents Chemother. 2007 Aug;51(8):2991-3. doi: 10.1128/AAC.00225-07. Epub 2007 Jun 11.
Abstract
Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.
摘要
使用青蒿素和OZ277（RBx11160）的非过氧化物类似物，结果显示后两种化合物强大的体外抗疟原虫活性依赖于过氧化物键。相比之下，青蒿素和OZ277对其他六种原生动物寄生虫的微弱活性则与过氧化物键无关。这些数据支持了铁依赖性青蒿素烷基化假说。
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