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Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin.在表现出万古霉素中介金黄色葡萄球菌型万古霉素耐药性的金黄色葡萄球菌临床分离株中细胞壁刺激子基因的过表达。
J Bacteriol. 2006 Feb;188(3):1120-33. doi: 10.1128/JB.188.3.1120-1133.2006.
2
Reduced expression of the atl autolysin gene and susceptibility to autolysis in clinical heterogeneous glycopeptide-intermediate Staphylococcus aureus (hGISA) and GISA strains.临床异质性糖肽类中介金黄色葡萄球菌（hGISA）和GISA菌株中atl自溶素基因表达降低及自溶敏感性
J Antimicrob Chemother. 2005 Nov;56(5):944-7. doi: 10.1093/jac/dki289. Epub 2005 Sep 12.
3
The escalating challenge of vancomycin resistance in Staphylococcus aureus.金黄色葡萄球菌中万古霉素耐药性不断升级的挑战。
Curr Drug Targets Infect Disord. 2004 Dec;4(4):273-94. doi: 10.2174/1568005043340470.
4
Cell wall composition and decreased autolytic activity and lysostaphin susceptibility of glycopeptide-intermediate Staphylococcus aureus.糖肽类中介金黄色葡萄球菌的细胞壁组成、自溶活性降低及对溶葡萄球菌素敏感性降低
Antimicrob Agents Chemother. 2004 Oct;48(10):3749-57. doi: 10.1128/AAC.48.10.3749-3757.2004.
5
tcaA inactivation increases glycopeptide resistance in Staphylococcus aureus.tcaA失活增加金黄色葡萄球菌对糖肽类抗生素的耐药性。
Antimicrob Agents Chemother. 2004 Jun;48(6):1953-9. doi: 10.1128/AAC.48.6.1953-1959.2004.
6
Alterations of cell wall structure and metabolism accompany reduced susceptibility to vancomycin in an isogenic series of clinical isolates of Staphylococcus aureus.在金黄色葡萄球菌临床分离株的同基因系列中，细胞壁结构和代谢的改变伴随着对万古霉素敏感性的降低。
J Bacteriol. 2003 Dec;185(24):7103-10. doi: 10.1128/JB.185.24.7103-7110.2003.
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Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.在万古霉素筛选的金黄色葡萄球菌分离株中，对自溶的抗性先于万古霉素中介抗性出现。
Antimicrob Agents Chemother. 2003 Jun;47(6):2036-9. doi: 10.1128/AAC.47.6.2036-2039.2003.
8
Staphylococcus aureus accessory gene regulator (agr) group II: is there a relationship to the development of intermediate-level glycopeptide resistance?金黄色葡萄球菌附属基因调节因子（agr）II组：与中度糖肽类耐药的发生有关吗？
J Infect Dis. 2003 Mar 15;187(6):929-38. doi: 10.1086/368128. Epub 2003 Mar 6.
9
Molecular characterization of an atl null mutant of Staphylococcus aureus.金黄色葡萄球菌atl基因敲除突变体的分子特征分析
Microbiol Immunol. 2002;46(9):601-12. doi: 10.1111/j.1348-0421.2002.tb02741.x.
10
Development of vancomycin and lysostaphin resistance in a methicillin-resistant Staphylococcus aureus isolate.一株耐甲氧西林金黄色葡萄球菌中万古霉素和溶葡萄球菌素耐药性的产生
J Antimicrob Chemother. 2001 Nov;48(5):617-25. doi: 10.1093/jac/48.5.617.

糖肽中介金黄色葡萄球菌Mu50的自溶特性

Autolytic properties of glycopeptide-intermediate Staphylococcus aureus Mu50.

作者信息

Utaida Sugunya, Pfeltz Richard F, Jayaswal R K, Wilkinson B J

机构信息

Microbiology Group, Department of Biological Sciences, 210 Julian Hall, Illinois State University, Normal, Illinois 61790-4120, USA.

出版信息

Antimicrob Agents Chemother. 2006 Apr;50(4):1541-5. doi: 10.1128/AAC.50.4.1541-1545.2006.

DOI:10.1128/AAC.50.4.1541-1545.2006
PMID:16569879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1426971/
Abstract

Whole-cell autolytic activity of prototypical glycopeptide-intermediate Staphylococcus aureus (GISA) Mu50 was reduced versus that of hetero-GISA Mu3 and glycopeptide-susceptible S. aureus, consistent with other GISA strains. In contrast, autolytic activity was relatively high in Mu50 crude cell walls and autolysin extracts against purified cell walls, reflecting the complexities of autolytic activity regulation.

摘要

与异源糖肽中介金黄色葡萄球菌（GISA）Mu3和糖肽敏感金黄色葡萄球菌相比，典型糖肽中介金黄色葡萄球菌（GISA）Mu50的全细胞自溶活性降低，这与其他GISA菌株一致。相比之下，Mu50粗细胞壁和自溶素提取物对纯化细胞壁的自溶活性相对较高，这反映了自溶活性调节的复杂性。