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在万古霉素筛选的金黄色葡萄球菌分离株中，对自溶的抗性先于万古霉素中介抗性出现。

Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.

作者信息

Boyle-Vavra Susan, Challapalli Mamatha, Daum Robert S

机构信息

Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA.

出版信息

Antimicrob Agents Chemother. 2003 Jun;47(6):2036-9. doi: 10.1128/AAC.47.6.2036-2039.2003.

DOI:10.1128/AAC.47.6.2036-2039.2003
PMID:12760894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC155830/
Abstract

Four clinical U.S. glycopeptide intermediate resistant Staphylococcus aureus (GISA) isolates were resistant to Triton X-100-induced autolysis. Similar resistance was demonstrated in an isolate obtained after a single passage of a susceptible clinical isolate in low-level vancomycin. Strains with the vancomycin-induced Triton X-100 resistance phenotype produced active murein hydrolases but were resistant to lysis by murein hydrolases.

摘要

美国的4株临床糖肽类中介耐药金黄色葡萄球菌（GISA）分离株对Triton X-100诱导的自溶具有抗性。在一株敏感临床分离株在低水平万古霉素中传代一次后获得的分离株中也表现出类似的抗性。具有万古霉素诱导的Triton X-100抗性表型的菌株产生活性胞壁质水解酶，但对胞壁质水解酶的裂解具有抗性。

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本文引用的文献

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Development of vancomycin and lysostaphin resistance in a methicillin-resistant Staphylococcus aureus isolate.一株耐甲氧西林金黄色葡萄球菌中万古霉素和溶葡萄球菌素耐药性的产生
J Antimicrob Chemother. 2001 Nov;48(5):617-25. doi: 10.1093/jac/48.5.617.
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Whole genome sequencing of meticillin-resistant Staphylococcus aureus.耐甲氧西林金黄色葡萄球菌的全基因组测序
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Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.控制金黄色葡萄球菌lrgAB表达的遗传元件分析：DNA拓扑结构在SarA调控中的潜在作用
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A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus.一种参与金黄色葡萄球菌黏附、自溶及细胞外蛋白水解活性的新型双组分调节系统。
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The Staphylococcus aureus lrgAB operon modulates murein hydrolase activity and penicillin tolerance.金黄色葡萄球菌lrgAB操纵子调节胞壁质水解酶活性和青霉素耐受性。
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Characterization of passage-selected vancomycin-resistant Staphylococcus aureus strains of diverse parental backgrounds.不同亲本背景的传代选择耐万古霉素金黄色葡萄球菌菌株的特性分析
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Staphylococcus aureus with reduced susceptibility to vancomycin isolated from a patient with fatal bacteremia.从一名患有致命菌血症的患者身上分离出的对万古霉素敏感性降低的金黄色葡萄球菌。
Emerg Infect Dis. 1999 Jan-Feb;5(1):147-9. doi: 10.3201/eid0501.990118.
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The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection.一名耐甲氧西林金黄色葡萄球菌感染患者中万古霉素耐药性的产生。
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Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50.在耐甲氧西林金黄色葡萄球菌临床菌株Mu3和Mu50中，活化的细胞壁合成与万古霉素耐药性相关。
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