在万古霉素筛选的金黄色葡萄球菌分离株中，对自溶的抗性先于万古霉素中介抗性出现。
Resistance to autolysis in vancomycin-selected Staphylococcus aureus isolates precedes vancomycin-intermediate resistance.
作者信息
Boyle-Vavra Susan, Challapalli Mamatha, Daum Robert S
机构信息
Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Antimicrob Agents Chemother. 2003 Jun;47(6):2036-9. doi: 10.1128/AAC.47.6.2036-2039.2003.
Abstract
Four clinical U.S. glycopeptide intermediate resistant Staphylococcus aureus (GISA) isolates were resistant to Triton X-100-induced autolysis. Similar resistance was demonstrated in an isolate obtained after a single passage of a susceptible clinical isolate in low-level vancomycin. Strains with the vancomycin-induced Triton X-100 resistance phenotype produced active murein hydrolases but were resistant to lysis by murein hydrolases.
摘要
美国的4株临床糖肽类中介耐药金黄色葡萄球菌（GISA）分离株对Triton X-100诱导的自溶具有抗性。在一株敏感临床分离株在低水平万古霉素中传代一次后获得的分离株中也表现出类似的抗性。具有万古霉素诱导的Triton X-100抗性表型的菌株产生活性胞壁质水解酶，但对胞壁质水解酶的裂解具有抗性。
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