肠炎沙门氏菌维尔肖血清型临床菌株中的大型接合质粒除了含有1类整合子和几个与整合子无关的耐药决定簇外，还含有一个2类整合子。
Large conjugative plasmids from clinical strains of Salmonella enterica serovar virchow contain a class 2 integron in addition to class 1 integrons and several non-integron-associated drug resistance determinants.
作者信息
Rodríguez Irene, Rodicio M Rosario, Mendoza M Carmen, Cruz Martín M
机构信息
Departamento de Biología Funcional-Microbiología, Universidad de Oviedo, Julián Clavería no. 6, 33006-Oviedo, Spain.
出版信息
Antimicrob Agents Chemother. 2006 Apr;50(4):1603-7. doi: 10.1128/AAC.50.4.1603-1607.2006.
Abstract
Two large conjugative resistance (R) plasmids from clinical strains of Salmonella enterica serovar Virchow carried a class 2 integron with the 5' conserved sequence (5'CS)-dfrA1-sat1-aadA1-3'CS gene array, which is associated with defective Tn7 transposons. In addition, each contained a different class 1 integron (with 5'CS-aadA1-3'CS or 5'CS-sat-smr-aadA1-3'CS gene arrays) linked to Tn21-Tn9 sequences, and several non-integron-associated R determinants. An intact copy of Tn7 (including the class 2 integron) was present in the chromosome of each strain.
摘要
来自肠炎沙门氏菌维氏血清型临床菌株的两个大型接合耐药（R）质粒携带一个2类整合子，其具有5'保守序列（5'CS）-dfrA1-sat1-aadA1-3'CS基因阵列，这与缺陷型Tn7转座子相关。此外，每个质粒都包含一个与Tn21-Tn9序列相连的不同的1类整合子（具有5'CS-aadA1-3'CS或5'CS-sat-smr-aadA1-3'CS基因阵列），以及几个与整合子无关的R决定簇。每个菌株的染色体中都存在一个完整的Tn7拷贝（包括2类整合子）。
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