15年间（1988年至2003年）西班牙一家医院产超广谱β-内酰胺酶肠杆菌科细菌中整合子类型的保存情况。
Preservation of integron types among Enterobacteriaceae producing extended-spectrum beta-lactamases in a Spanish hospital over a 15-year period (1988 to 2003).
作者信息
Machado Elisabete, Ferreira Joana, Novais Angela, Peixe Luísa, Cantón Rafael, Baquero Fernando, Coque Teresa M
机构信息
Servicio de Microbiología, Hospital Universitario Ramón y Cajal. Carretera de Colmenar, km. 9.1. Madrid 28034, Spain.
出版信息
Antimicrob Agents Chemother. 2007 Jun;51(6):2201-4. doi: 10.1128/AAC.01389-06. Epub 2007 Apr 2.
Abstract
The variable presence of integrons among extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae species (0 to 66%) is described. Association between bla(ESBL) and integrons occurred when these are linked to specific ESBL-type genes (In60 bearing ISCR1 and bla(CTX-M-9)) or when ESBL genes were superimposed onto selected plasmids carrying integrons. Some integrons were identical to those found during decades worldwide, illustrating the preservation of the genetic elements carrying them.
摘要
研究描述了产超广谱β-内酰胺酶（ESBL）的肠杆菌科细菌中整合子的存在情况各异（0%至66%）。当bla(ESBL)与整合子与特定的ESBL型基因相关联（携带ISCR1和bla(CTX-M-9)的In60），或者当ESBL基因叠加在携带整合子的特定质粒上时，bla(ESBL)与整合子之间存在关联。一些整合子与全球数十年来发现的整合子相同，这表明携带它们的遗传元件得以保存。
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