Hill Tom R, O'Brien Maria M, Lamberg-Allardt Christel, Jakobsen Jette, Kiely Mairead, Flynn Albert, Cashman Kevin D
Department of Food and Nutritional Sciences, University College, Cork, Ireland.
Public Health Nutr. 2006 Apr;9(2):225-33. doi: 10.1079/phn2005837.
To assess the vitamin D status of Irish postmenopausal women during wintertime, and to examine its relationship with serum parathyroid hormone (PTH) and biochemical markers of bone turnover. In addition, the determinants of wintertime serum 25-hydroxyvitamin D (25OH-D) levels in these women were investigated.
A cross-sectional observational study.
Cork City, Ireland (52 degrees N).
Ninety-five apparently healthy, free-living postmenopausal women (aged 51-75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism.
Forty-eight per cent and 7% of women had serum 25OH-D levels <50 nmol l(-1) and <25 nmol l(-1), respectively. 25OH-D levels in these women were positively associated with dietary calcium intake (P = 0.0002) and use of vitamin D-containing supplements (P = 0.031), and negatively associated with cigarette smoking (P = 0.027) and body mass index (BMI) (P = 0.030). Low serum 25OH-D levels (<50 nmol l(-1)) were associated (P < 0.01) with elevated serum PTH levels. There were no significant differences in urinary pyridinium crosslinks or serum osteocalcin, biochemical indices of bone turnover, between subjects with serum 25OH-D levels above or below 50 nmol l(-1).
A high proportion of Irish postmenopausal women had low vitamin D status (<50 nmol l(-1)) during late wintertime, which appeared to lead to elevated levels of serum PTH but not of bone turnover markers. Use of regular low-dose supplemental vitamin D, meeting daily calcium recommendations, cessation of smoking and maintaining BMI in the normal range are important factors that could help maintain adequate vitamin D levels during wintertime in these women.
评估爱尔兰绝经后女性冬季的维生素D状况，并研究其与血清甲状旁腺激素（PTH）及骨转换生化标志物的关系。此外，还对这些女性冬季血清25-羟维生素D（25OH-D）水平的决定因素进行了调查。
一项横断面观察性研究。
爱尔兰科克市（北纬52度）。
95名明显健康、自由生活的绝经后女性（年龄51 - 75岁），未服用任何药物，且无任何可能影响维生素D状况或钙/骨代谢的疾病。
分别有48%和7%的女性血清25OH-D水平<50 nmol l⁻¹和<25 nmol l⁻¹。这些女性的25OH-D水平与膳食钙摄入量呈正相关（P = 0.0002），与使用含维生素D的补充剂呈正相关（P = 0.031），与吸烟呈负相关（P = 0.027），与体重指数（BMI）呈负相关（P = 0.030）。血清25OH-D水平低（<50 nmol l⁻¹）与血清PTH水平升高相关（P < 0.01）。血清25OH-D水平高于或低于50 nmol l⁻¹的受试者之间，尿吡啶交联物或血清骨钙素（骨转换的生化指标）无显著差异。
在冬末，很大比例的爱尔兰绝经后女性维生素D状况较低（<50 nmol l⁻¹），这似乎导致血清PTH水平升高，但未导致骨转换标志物水平升高。定期使用低剂量补充维生素D、满足每日钙推荐摄入量、戒烟以及将BMI维持在正常范围内，是有助于这些女性在冬季维持充足维生素D水平的重要因素。
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