佛波二丁酸酯对爱泼斯坦-巴尔病毒转化的人B淋巴细胞中游离鞘氨醇水平的调节作用。
Modulation of the free sphingosine levels in Epstein Barr virus transformed human B lymphocytes by phorbol dibutyrate.
作者信息
Miccheli A, Ricciolini R, Lagana A, Piccolella E, Conti F
机构信息
Department of Chemistry, University La Sapienza, Rome, Italy.
出版信息
Biochim Biophys Acta. 1991 Oct 16;1095(1):90-2. doi: 10.1016/0167-4889(91)90049-4.
The amounts of free sphingosine in Epstein Barr virus transformed B lymphocytes (EBV-B) treated with sphingosine and phorbol-12,13-dibutyrate (PD) has been quantified by high performance liquid chromatography (HPLC). PD treatment did not affect intracellular sphingosine level, while it seems to lessen the removal of this long chain base in sphingosine-treated EBV-B cells. The previous results relative to sphingosine-dependent changes in choline-metabolite levels have to be interpreted on the basis of these results.
用高效液相色谱法（HPLC）对经鞘氨醇和佛波醇-12,13-二丁酸酯（PD）处理的爱泼斯坦-巴尔病毒转化B淋巴细胞（EBV-B）中的游离鞘氨醇含量进行了定量。PD处理不影响细胞内鞘氨醇水平，而它似乎减少了鞘氨醇处理的EBV-B细胞中这种长链碱基的清除。必须基于这些结果来解释先前关于鞘氨醇依赖性胆碱代谢物水平变化的结果。
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