[低浓度5-氟尿嘧啶皮损内注射治疗瘢痕疙瘩的临床研究]
[Clinical study on keloid treatment with intralesional injection of low concentration 5-fluorouracil].
作者信息
Wu Xiao-li, Liu Wei, Cao Yi-lin
机构信息
Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
出版信息
Zhonghua Zheng Xing Wai Ke Za Zhi. 2006 Jan;22(1):44-6.
OBJECTIVE
To explore the effect of intralesional injection of low concentration 5-fluorouracil (5-FU) on inhibition of angiogenesis of keloid.
METHODS
35 patients with 51 keloids were treated with intralesional injection of 5-FU (2-5 mg/ml) biweekly. After 3-6 times of injection, the keloids were treated with intralesional injection of corticosteroid. The average period of treatment was 10.29 months.
RESULTS
The efficacy of inhibiting keloid angiogenesis by low concentration of 5-fluorouracil was 96.77%. For the patients who were treated over 6 months with both 5-FU and corticosteroid, the total efficacy was 97.14%. Among them, 45.71% of keloids achieved complete remission, 48.57% mostly remission, 2.86% partial remission and 2.86% no remission.
CONCLUSION
Inhibition of keloid angiogenesis with intralesional injection of low concentration of 5-fluorouracil along with corticosteroid injection can achieve satisfactory result.
目的
探讨病灶内注射低浓度5-氟尿嘧啶（5-FU）对瘢痕疙瘩血管生成的抑制作用。
方法
35例患者共51个瘢痕疙瘩，每两周接受一次病灶内注射5-FU（2-5mg/ml）治疗。注射3-6次后，瘢痕疙瘩再接受病灶内注射皮质类固醇治疗。平均治疗周期为10.29个月。
结果
低浓度5-氟尿嘧啶抑制瘢痕疙瘩血管生成的有效率为96.77%。接受5-FU和皮质类固醇联合治疗超过6个月的患者，总有效率为97.14%。其中，45.71%的瘢痕疙瘩完全缓解，48.57%大部分缓解，2.86%部分缓解，2.86%未缓解。
结论
病灶内注射低浓度5-氟尿嘧啶联合皮质类固醇注射抑制瘢痕疙瘩血管生成可取得满意效果。
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