Srivastava Monika
Ronald O. Perelman Department of Dermatology, NYU School of Medicine, USA.
J Drugs Dermatol. 2006 Mar;5(3):279-80.
A 71-year-old woman with a history of Sjögren's syndrome presented for evaluation of a waxy nodule present on the scalp for 6 months. Histopathologic examination revealed deposition of homogenous eosinophilic material throughout the reticular dermis consistent with amyloidosis. Primary cutaneous nodular amyloidosis is a rare phenomenon characterized by the deposition of immunoglobin light chains by a clonal plasma cell population. Patients need to be monitored for progression to systemic amyloidosis or plasma cell dyscrasias.
一名71岁患有干燥综合征的女性因头皮出现蜡样结节6个月前来评估。组织病理学检查显示，整个网状真皮层均有均匀嗜酸性物质沉积，符合淀粉样变。原发性皮肤结节性淀粉样变是一种罕见现象，其特征为克隆性浆细胞群体沉积免疫球蛋白轻链。需要对患者进行监测，以观察是否进展为系统性淀粉样变或浆细胞发育异常疾病。
