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正常血压的津巴布韦人红细胞内钠和钾的浓度以及哇巴因诱导的钠钾通量

Intracellular concentrations and ouabain-induced fluxes of sodium and potassium in erythrocytes of normotensive Zimbabweans.

作者信息

Mubagwa K, Wagaine-Twabwe D, Matimba N

机构信息

Department of Pharmacology, University of Connecticut Farmington 06032.

出版信息

Cent Afr J Med. 1991 Apr;37(4):114-20.

PMID:1657397
Abstract

Intracellular Na and K concentrations as well as ouabain-induced transmembrane net Na and K fluxes were measures in erythrocytes (TBC) of 22 adult Black male Zimbabweans. The intracellular Na concentration was 9.1 +/- 0.44 mmol/l RBC, the K concentration 90.7 +/- 1.33 mmol/l RBC and the ouabain (0.1 mM)-induced Na influx 1.55 +/- 0.132 mmol/hr.1 RBC. The intracellular Na concentration is higher than most values reported from studies of Whites, but the intracellular K concentration and the ouabain-induced Na influx compare with literature values. No significant correlation was found between intracellular Na concentration and blood pressure.

摘要

对22名成年津巴布韦黑人男性的红细胞(TBC)中的细胞内钠和钾浓度以及哇巴因诱导的跨膜净钠和钾通量进行了测量。细胞内钠浓度为9.1±0.44 mmol/l红细胞,钾浓度为90.7±1.33 mmol/l红细胞,哇巴因(0.1 mM)诱导的钠内流为1.55±0.132 mmol/小时·1红细胞。细胞内钠浓度高于大多数关于白人的研究报告值,但细胞内钾浓度和哇巴因诱导的钠内流与文献值相当。未发现细胞内钠浓度与血压之间存在显著相关性。

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