Prasad R, Mond R, Jain S, Kaur G, Chugh K S
Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Biochem Mol Biol Int. 1996 Dec;40(6):1087-94. doi: 10.1080/15216549600201723.
Significantly higher levels of plasma urea creatinine and potassium were observed in patients with renal failure compared to normal controls. The RBC sodium concentration was raised whereas the RBC potassium concentration was decreased in chronic renal failure. These alterations in the RBC Na+ and K+ concentrations were associated with decrease in ouabain sensitive sodium efflux rate and ouabain sensitive sodium efflux rate constant. However, there was no significant impact of acute hemodialysis on the intracellular electrolytes levels, ouabain sensitive sodium efflux rate and ouabain sensitive sodium efflux rate constant. These findings suggest an intrinsic alteration in the transport capacity of Na(+)-K+ pump which could account for the rise in intracellular sodium and fall in intracellular potassium content in the RBCs of chronic renal failure patients.
与正常对照组相比，肾衰竭患者血浆尿素肌酐和钾水平显著升高。慢性肾衰竭患者红细胞钠浓度升高而红细胞钾浓度降低。红细胞钠和钾浓度的这些变化与哇巴因敏感钠外流率及哇巴因敏感钠外流速率常数降低有关。然而，急性血液透析对细胞内电解质水平、哇巴因敏感钠外流率及哇巴因敏感钠外流速率常数无显著影响。这些发现提示钠钾泵转运能力存在内在改变，这可能是慢性肾衰竭患者红细胞内钠含量升高及钾含量降低的原因。
