与文拉法辛给药相关的QT间期延长。

QT interval prolongation associated with venlafaxine administration.

作者信息

Letsas Konstantinos, Korantzopoulos Panagiotis, Pappas Loucas, Evangelou Dimitrios, Efremidis Michalis, Kardaras Fotis

出版信息

Int J Cardiol. 2006 Apr 28;109(1):116-7. doi: 10.1016/j.ijcard.2005.03.065.

DOI:10.1016/j.ijcard.2005.03.065

Abstract

A significant number of non-antiarrhythmic drugs including psychotropic agents have been shown to prolong cardiac repolarization increasing the risk for torsade de pointes ventricular tachycardia. We briefly describe a 60-year-old woman who admitted to the hospital due to hypertension and mild dyspnea having a prolonged QT interval (QTc: 582 ms). The patient had a known history of depression treated with venlafaxine. The QT interval normalised a few days after cessation of the antidepressant agent. This is the first report of venlafaxine-induced QT interval prolongation.

摘要

大量非抗心律失常药物，包括精神药物，已被证明会延长心脏复极，增加尖端扭转型室性心动过速的风险。我们简要描述一名60岁女性，因高血压和轻度呼吸困难入院，其QT间期延长（校正QT间期：582毫秒）。该患者有抑郁症病史，一直用文拉法辛治疗。停用抗抑郁药几天后，QT间期恢复正常。这是文拉法辛引起QT间期延长的首例报告。