Deshmukh Anand, Ulveling Kyle, Alla Venkata, Abuissa Hussam, Airey Kelly
Department of Cardiovascular Medicine, The Cardiac Center of Creighton University, Omaha, Nebraska 68131, USA.
Tex Heart Inst J. 2012;39(1):68-70.
Citalopram is a selective serotonin reuptake inhibitor with a favorable cardiac-safety profile. Corrected QT interval (QTc) prolongation and cardiac arrhythmias have not been previously reported in association with citalopram use except in the presence of overdose, abnormal electrolyte values, or renal or liver failure. Herein, we report the case of a 40-year-old woman with mental depression who presented with a prolonged QTc interval and torsades de pointes after the initiation of citalopram at therapeutic doses. The QTc interval improved when citalopram therapy was discontinued. We recommend that clinicians investigate the family history for sudden deaths and perform baseline electrocardiography before prescribing citalopram. We also recommend routine electrocardiographic testing during citalopram therapy, and that patients with long QT syndrome avoid taking citalopram.
西酞普兰是一种选择性5-羟色胺再摄取抑制剂，具有良好的心脏安全性。除了过量用药、电解质值异常或存在肾或肝功能衰竭的情况外，此前尚未有与使用西酞普兰相关的校正QT间期（QTc）延长和心律失常的报道。在此，我们报告一例40岁患有精神抑郁症的女性病例，该患者在开始使用治疗剂量的西酞普兰后出现QTc间期延长和尖端扭转型室性心动过速。停用西酞普兰治疗后，QTc间期有所改善。我们建议临床医生在开具西酞普兰处方前调查患者家族猝死史并进行基线心电图检查。我们还建议在西酞普兰治疗期间进行常规心电图检测，并且长QT综合征患者应避免服用西酞普兰。
