Eide P K, Sorteberg W
Department of Neurosurgery, The National Hospital, Rikshospitalet, 0027, Oslo, Norway.
Br J Neurosurg. 2005 Dec;19(6):475-83. doi: 10.1080/02688690500495125.
Nineteen consecutive cases treated for idiopathic normal pressure hydrocephalus (iNPH) with ventriculo-peritoneal shunts were clinically followed prospectively. Change in clinical state one year after shunt surgery was assessed as change on a 15-3 score NPH Grade Scale. Preoperative spinal hydrodynamics were assessed using a constant-rate lumbar infusion test. The pressure recordings were stored as raw data files and analysed retrospectively with regard to the mean cerebrospinal fluid pressure (CSFP), as well as mean CSFP wave amplitudes. Changes in NPH score 1 year after shunt surgery correlated significantly with the levels of single CSFP wave amplitudes, but not with the lumbar resistance to CSF outflow (R(out)). Mean CSFP wave amplitude was thus, in this cohort, a better predictor of clinical change one year after shunt treatment than R(out).
对19例接受脑室-腹腔分流术治疗特发性正常压力脑积水（iNPH）的连续病例进行了前瞻性临床随访。分流手术后一年临床状态的变化根据15-3分NPH分级量表进行评估。术前采用恒速腰椎灌注试验评估脊髓流体动力学。压力记录作为原始数据文件存储，并回顾性分析脑脊液平均压力（CSFP）以及CSFP平均波幅。分流手术后1年NPH评分的变化与单个CSFP波幅水平显著相关，但与脑脊液流出的腰椎阻力（R(out)）无关。因此，在该队列中，CSFP平均波幅比分流治疗后1年临床变化的R(out)是更好的预测指标。
