Xu G L
Shanghai Second Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1991 Sep;26(5):272-4, 322.
Human cytomegalovirus (HCMV)-IgG, IgM antibodies were detected by indirect ELISA in 103 serum specimens from women with history of abnormal pregnancy. The results showed that the positive rates of HCMV-IgG and IgM of abnormal pregnant women were 90.29% and 13.59% respectively. The positive rate of HCMV-IgM in abnormal pregnancies was higher than that of normal pregnancies (4.07%, P less than 0.001). This suggested that the probability of abnormal pregnancy in HCMV-IgM positive women was higher than the negative ones. Thus detecting HCMV-IgM by ELISA could be used not only in early diagnosis of active HCMV infection in pregnant women, but also a way to prevent this delivery of malformed babies.
采用间接酶联免疫吸附测定法（ELISA）检测了103例有异常妊娠史女性血清标本中的人巨细胞病毒（HCMV）-IgG和IgM抗体。结果显示，异常妊娠女性的HCMV-IgG和IgM阳性率分别为90.29%和13.59%。异常妊娠中HCMV-IgM的阳性率高于正常妊娠（4.07%，P<0.001）。这表明HCMV-IgM阳性女性发生异常妊娠的概率高于阴性女性。因此，通过ELISA检测HCMV-IgM不仅可用于孕妇活动性HCMV感染的早期诊断，也是预防畸形儿出生的一种方法。
