Cao Y, Li A
The Second Affiliated Hospital of Hubei Medical University, Wuhan 430071.
Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997 Sep;11(3):256-8.
In order to study the relationship between human cytomegalovirus infection and soluble interleukin-2 receptor (sIL-2R) level, 104 serum samples were selected from women of childbearing age in the city of Wuhan and examined with ELISA for anti-HCMV antibody IgG and IgM. Then we detected the sIL-2R level with double antibody ELISA in these sera with different conditions of HCMV infection. The results of different groups were compared with those women without cytomegalovirus infection and also compared with each other. The positive rate for anti-HCMV antibody IgG in the women of Wuhan was 89.4% (93/104) and for anti-HCMV antibody IgM only was 9.6% (10/104). The sIL-2R level of these women with HCMV infection was significantly higher than that in the control group (178.1 +/- 57.3 U/ml), P > 0.05. The highest level of sIL-2R were in those women whose anti-HCMV antibody IgM were positive (910 +/- 465.6 U/ml) and secondly was in those with anti-HCMV antibody IgG, IgM positive (905 +/- 347.8 U/ml). They were both higher than that in those women only with anti-HCMV antibody IgG positive (446.8 +/- 158.9 U/ml), P > 0.05. The results showed that HCMV infection can raise the sIL-2R level in serum of childbearing age women, especially in those with active HCMV infection. sIL-2R may be one of the pathogenic factors of HCMV.
为研究人巨细胞病毒（HCMV）感染与可溶性白细胞介素-2受体（sIL-2R）水平的关系，从武汉市育龄妇女中选取104份血清样本，采用酶联免疫吸附测定法（ELISA）检测抗HCMV抗体IgG和IgM。然后用双抗体ELISA法检测这些处于不同HCMV感染状态血清中的sIL-2R水平。将不同组的结果与未感染巨细胞病毒的女性进行比较，同时也进行组间比较。武汉女性抗HCMV抗体IgG的阳性率为89.4%（93/104），仅抗HCMV抗体IgM的阳性率为9.6%（10/104）。这些HCMV感染女性的sIL-2R水平显著高于对照组（178.1±57.3 U/ml），P>0.05。sIL-2R水平最高的是抗HCMV抗体IgM阳性的女性（910±465.6 U/ml），其次是抗HCMV抗体IgG、IgM均阳性的女性（905±347.8 U/ml）。它们均高于仅抗HCMV抗体IgG阳性的女性（446.8±158.9 U/ml），P>0.05。结果表明，HCMV感染可使育龄妇女血清中的sIL-2R水平升高，尤其是在HCMV活跃感染的妇女中。sIL-2R可能是HCMV的致病因素之一。
