Seifried E, Gabelmann A, Ellbrück D, Schmidt A
Abteilungen Innere Medizin III, Medizinische Universitätsklinik und Poliklinik, Ulm.
Geburtshilfe Frauenheilkd. 1991 Aug;51(8):655-8. doi: 10.1055/s-2007-1026418.
We report on successful thrombolytic treatment of massive pulmonary embolism in a patient in early pregnancy with recombinant tissue-type plasminogen activator (rt-PA). Therapy was started with 20 mg rt-PA intravenously over 20 minutes, followed by two further infusions of 20 mg rt-PA within the next 8 hours. Clinical symptoms and haemodynamic parameters improved 24 hours after initiation of therapy. No bleeding complications were observed and the foetus was not affected. Further thromboembolic episodes could be prevented by anticoagulation with low molecular weight heparin up to full term normal delivery.
我们报告了一例早孕患者使用重组组织型纤溶酶原激活剂（rt-PA）成功溶栓治疗大面积肺栓塞的病例。治疗开始时，先在20分钟内静脉注射20 mg rt-PA，随后在接下来的8小时内再进行两次20 mg rt-PA的输注。治疗开始24小时后，临床症状和血流动力学参数有所改善。未观察到出血并发症，胎儿也未受到影响。通过使用低分子肝素抗凝直至足月正常分娩，可预防进一步的血栓栓塞事件。
