Creamer H R, Hunter N, Bullock W W, Gabler W L
Department of Oral Microbiology/Immunology, School of Dentistry, Oregon Health Sciences University, Portland 97201-3097.
Inflammation. 1991 Jun;15(3):201-11. doi: 10.1007/BF00918646.
Polymorphonuclear neutrophil (PMN) function is thought to be critical in resistance to infectious agents and this implies that the PMN must be able to migrate into, and to function in, environments that may have high levels of bacterial lipopolysaccharide (LPS). Therefore, we have evaluated the effect of LPS on the in vitro migration of PMNs. Our data reveal that the human PMN is resistant to the deleterious effects of high levels of LPS, that in high concentrations LPS is, itself, a direct chemoattractant for PMNs, and that PMN migration toward a bacterial chemotaxin is enhanced if LPS is also present. Such capabilities suggest that the PMN may be uniquely qualified to migrate into microenvironments that are rich in LPS.
多形核中性粒细胞（PMN）的功能被认为在抵抗感染因子方面至关重要，这意味着PMN必须能够迁移到可能含有高水平细菌脂多糖（LPS）的环境中并在其中发挥作用。因此，我们评估了LPS对PMN体外迁移的影响。我们的数据显示，人类PMN对高水平LPS的有害作用具有抗性，高浓度的LPS本身就是PMN的直接趋化因子，并且如果同时存在LPS，PMN向细菌趋化因子的迁移会增强。这些能力表明PMN可能特别适合迁移到富含LPS的微环境中。
