Taneike Ikue, Otsuka Taketo, Dohmae Soshi, Saito Kohei, Ozaki Kyoko, Takano Misao, Higuchi Wataru, Takano Tomomi, Yamamoto Tatsuo
Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Niigata, Japan.
FEBS Lett. 2006 Apr 17;580(9):2323-34. doi: 10.1016/j.febslet.2006.03.049. Epub 2006 Mar 29.
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) with Panton-Valentine leukocidin (PVL) genes is increasing worldwide. Nosocomial outbreak-derived (hospital-acquired) MRSA (HA-MRSA) in Japan in the 1980s was also largely PVL(+). PVL(+) HA-MRSA and CA-MRSA shared the same multi-locus sequence type (ST30) and methicillin resistance cassette (SCCmecIV), but were divergent in oxacillin resistance, spa typing, PFGE analysis or clfA gene analysis. PVL(+) HA-MRSA, which probably originated in PVL(+)S. aureus ST30, was highly adhesive (carrying cna and bbp genes), highly-toxic (carrying luk(PV) and sea genes) and highly drug-resistant. PVL(+) HA-MRSA was once replaced by other PVL(-) HA-MRSA (e.g., ST5), and is re-emerging as CA-MRSA.
携带杀白细胞素（PVL）基因的社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）在全球范围内呈上升趋势。20世纪80年代日本医院内暴发的（医院获得性）耐甲氧西林金黄色葡萄球菌（HA-MRSA）也大多携带PVL基因（PVL阳性）。PVL阳性的HA-MRSA和CA-MRSA具有相同的多位点序列类型（ST30）和甲氧西林耐药基因盒（SCCmecIV），但在苯唑西林耐药性、spa分型、脉冲场凝胶电泳分析或clfA基因分析方面存在差异。PVL阳性的HA-MRSA可能起源于PVL阳性的金黄色葡萄球菌ST30，具有高黏附性（携带cna和bbp基因）、高毒性（携带luk(PV)和sea基因）和高耐药性。PVL阳性的HA-MRSA曾一度被其他PVL阴性的HA-MRSA（如ST5）取代，现在又作为CA-MRSA重新出现。
