Tristan Anne, Ferry Tristan, Durand Geraldine, Dauwalder Olivier, Bes Michele, Lina Gerard, Vandenesch François, Etienne Jerome
INSERM E0230, Lyon, France.
J Hosp Infect. 2007 Jun;65 Suppl 2:105-9. doi: 10.1016/S0195-6701(07)60025-5.
Staphylococcus aureus produces many virulence factors, most of which act in a synergistic and coordinated fashion. Some appear to be specifically associated with certain severe infections and are produced by meticillin-resistant Staphylococcus aureus (MRSA) clones distributed worldwide. Superantigenic exotoxins appear to be major virulence factors in hospital MRSA clones (HA-MRSA), and staphylococcal enterotoxin A (SEA) may be involved in the physiopathology of septic shock. Panton Valentine Leucocidin (PVL) has emerged as a major virulence factor in community-acquired Staphylococcus aureus (CA-MRSA) infections. In particular, the leukotoxic action of PVL is responsible for the high mortality rate associated with necrotizing pneumonia. CA-MRSA can also harbour the toxic shock toxin 1 (TSST-1) and rarely the exfoliative toxin.
金黄色葡萄球菌产生多种毒力因子，其中大多数以协同和协调的方式发挥作用。有些毒力因子似乎与某些严重感染特别相关，并且由分布在世界各地的耐甲氧西林金黄色葡萄球菌（MRSA）克隆产生。超抗原性外毒素似乎是医院MRSA克隆（HA-MRSA）中的主要毒力因子，而葡萄球菌肠毒素A（SEA）可能参与感染性休克的病理生理学过程。杀白细胞素（PVL）已成为社区获得性金黄色葡萄球菌（CA-MRSA）感染中的主要毒力因子。特别是，PVL的白细胞毒性作用是导致坏死性肺炎相关高死亡率的原因。CA-MRSA还可携带中毒性休克综合征毒素1（TSST-1），很少携带剥脱毒素。
