端粒缩短与情绪障碍：对加速衰老的慢性应激模型的初步支持。
Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.
作者信息
Simon Naomi M, Smoller Jordan W, McNamara Kate L, Maser Richard S, Zalta Alyson K, Pollack Mark H, Nierenberg Andrew A, Fava Maurizio, Wong Kwok-Kin
机构信息
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
出版信息
Biol Psychiatry. 2006 Sep 1;60(5):432-5. doi: 10.1016/j.biopsych.2006.02.004. Epub 2006 Apr 11.
BACKGROUND
Little is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders. Substantial evidence supports abnormalities in stress-related biological systems in depression. Accelerated telomere shortening may reflect stress-related oxidative damage to cells and accelerated aging, and severe psychosocial stress has been linked to telomere shortening. We propose that chronic stress associated with mood disorders may contribute to excess vulnerability for diseases of aging such as cardiovascular disease and possibly some cancers through accelerated organismal aging.
METHODS
Telomere length was measured by Southern Analysis in 44 individuals with chronic mood disorders and 44 nonpsychiatrically ill age-matched control subjects.
RESULTS
Telomere length was significantly shorter in those with mood disorders, representing as much as 10 years of accelerated aging.
CONCLUSIONS
These results provide preliminary evidence that mood disorders are associated with accelerated aging and may suggest a novel mechanism for mood disorder-associated morbidity and mortality.
背景
关于情绪障碍所伴随的过多医疗发病率和死亡率背后的生物学机制，我们了解甚少。大量证据支持抑郁症中与应激相关的生物系统存在异常。端粒加速缩短可能反映了与应激相关的细胞氧化损伤和加速衰老，并且严重的心理社会应激已与端粒缩短相关联。我们提出，与情绪障碍相关的慢性应激可能通过加速机体衰老，导致对诸如心血管疾病和某些癌症等衰老相关疾病的易感性增加。
方法
通过Southern分析测量了44例慢性情绪障碍患者和44例年龄匹配的非精神疾病对照受试者的端粒长度。
结果
情绪障碍患者的端粒长度明显更短，相当于加速衰老了10年。
结论
这些结果提供了初步证据，表明情绪障碍与加速衰老相关，并可能提示了一种与情绪障碍相关的发病率和死亡率的新机制。
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