Majdan Marta, Shatz Carla J
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA.
Nat Neurosci. 2006 May;9(5):650-9. doi: 10.1038/nn1674. Epub 2006 Apr 2.
There are critical periods in development when sensory experience directs the maturation of synapses and circuits within neocortex. We report that the critical period in mouse visual cortex has a specific molecular logic of gene regulation. Four days of visual deprivation regulated one set of genes during the critical period, and different sets before or after. Dark rearing perturbed the regulation of these age-specific gene sets. In addition, a 'common gene set', comprised of target genes belonging to a mitogen-activated protein (MAP) kinase signaling pathway, was regulated by vision at all ages but was impervious to prior history of sensory experience. Together, our results demonstrate that vision has dual effects on gene regulation in visual cortex and that sensory experience is needed for the sequential acquisition of age-specific, but not common, gene sets. Thus, a dynamic interplay between experience and gene expression drives activity-dependent circuit maturation.
在发育过程中存在关键期，此时感觉经验引导新皮层内突触和神经回路的成熟。我们报告称，小鼠视觉皮层的关键期具有特定的基因调控分子逻辑。四天的视觉剥夺在关键期调控了一组基因，而在关键期之前或之后则调控不同的基因集。暗饲养扰乱了这些年龄特异性基因集的调控。此外，一个“共同基因集”，由属于丝裂原活化蛋白（MAP）激酶信号通路的靶基因组成，在所有年龄段都受视觉调控，但不受先前感觉经验历史的影响。总之，我们的结果表明，视觉对视觉皮层中的基因调控具有双重作用，并且感觉经验是按顺序获取年龄特异性而非共同基因集所必需的。因此，经验与基因表达之间的动态相互作用驱动了活动依赖的神经回路成熟。
