Di Cristo Graziella, Chattopadhyaya Bidisha, Kuhlman Sandra J, Fu Yu, Bélanger Marie-Claude, Wu Cai Zhi, Rutishauser Urs, Maffei Lamberto, Huang Z Josh
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11734, USA.
Nat Neurosci. 2007 Dec;10(12):1569-77. doi: 10.1038/nn2008. Epub 2007 Nov 18.
Functional maturation of GABAergic innervation in the developing visual cortex is regulated by neural activity and sensory inputs and in turn influences the critical period of ocular dominance plasticity. Here we show that polysialic acid (PSA), presented by the neural cell adhesion molecule, has a role in the maturation of GABAergic innervation and ocular dominance plasticity. Concentrations of PSA significantly decline shortly after eye opening in the adolescent mouse visual cortex; this decline is hindered by visual deprivation. The developmental and activity-dependent regulation of PSA expression is inversely correlated with the maturation of GABAergic innervation. Premature removal of PSA in visual cortex results in precocious maturation of perisomatic innervation by basket interneurons, enhanced inhibitory synaptic transmission, and earlier onset of ocular dominance plasticity. The developmental and activity-dependent decline of PSA expression therefore regulates the timing of the maturation of GABAergic inhibition and the onset of ocular dominance plasticity.
发育中的视觉皮层中GABA能神经支配的功能成熟受神经活动和感觉输入的调节，反过来又影响眼优势可塑性的关键期。在这里，我们表明由神经细胞粘附分子呈现的多唾液酸（PSA）在GABA能神经支配的成熟和眼优势可塑性中起作用。在青春期小鼠视觉皮层睁眼后不久，PSA的浓度显著下降；这种下降受到视觉剥夺的阻碍。PSA表达的发育和活动依赖性调节与GABA能神经支配的成熟呈负相关。过早去除视觉皮层中的PSA会导致篮状中间神经元对躯体周围神经支配的早熟、抑制性突触传递增强以及眼优势可塑性的更早出现。因此，PSA表达的发育和活动依赖性下降调节了GABA能抑制成熟的时间和眼优势可塑性的开始。
