Sifrim Daniel, Blondeau Kathleen
Centre for Gastroenterological Research, KU Leuven, Belgium.
Nat Clin Pract Gastroenterol Hepatol. 2006 Apr;3(4):210-9. doi: 10.1038/ncpgasthep0446.
Classic techniques like videofluoroscopy, stationary manometry, and ambulatory 24 h pH-metry are routinely used in the clinic to study patients with dysphagia, chest pain and reflux-related symptoms. Although these techniques have been very useful over the years, both for diagnosis and for therapeutic guidance, there are still many patients with dysphagia or chest pain who remain undiagnosed even after testing, and patients with typical and atypical symptoms of gastroesophageal reflux disease, with normal pH-metry findings, who do not respond adequately to antisecretory therapy. Esophageal impedance monitoring is a new technique that can be used alone and in combination with pH-metry and manometry to evaluate bolus transport and all types of gastroesophageal reflux (acid and nonacid). This review describes the esophageal impedance monitoring technique and summarizes the published validation studies that compare impedance monitoring with other methods, as well as normal values and reproducibility of impedance patterns and their association with symptoms.
诸如电视荧光吞咽造影、静态测压法和动态24小时pH值监测等经典技术在临床上常用于研究吞咽困难、胸痛及反流相关症状的患者。尽管这些技术多年来在诊断和治疗指导方面都非常有用，但仍有许多吞咽困难或胸痛患者即使经过检查仍未确诊，还有一些胃食管反流病典型和非典型症状患者，其pH值监测结果正常，但对抗分泌治疗反应不佳。食管阻抗监测是一项新技术，可单独使用，也可与pH值监测和测压法联合使用，以评估食团运输及各种类型的胃食管反流（酸性和非酸性）。本文综述了食管阻抗监测技术，并总结了已发表的验证研究，这些研究比较了阻抗监测与其他方法，以及阻抗模式的正常值、可重复性及其与症状的关联。
