Moreau Louis, Ziarelli Fabio, Grinstaff Mark W, Barthélémy Philippe
Inserm, U386, Bordeaux, F-33076 France.
Chem Commun (Camb). 2006 Apr 21(15):1661-3. doi: 10.1039/b601038e. Epub 2006 Mar 7.
Hollow microspheres featuring a hybrid lipid-cation multilamellar shell are prepared by hydration of a nucleoside based amphiphile with an aqueous solution containing either actinide or lanthanide salts. The physico-chemical data collected clearly indicate that the formation of these microspheres is a consequence of the following concomitant stabilizing factors: (i) hydrophobic interactions, (ii) nucleobase dimer formation and (iii) phosphate/f-block element salt binding.
通过使基于核苷的两亲物与含有锕系元素盐或镧系元素盐的水溶液水合，制备出具有脂质-阳离子混合多层壳的中空微球。收集到的物理化学数据清楚地表明，这些微球的形成是以下协同稳定因素的结果：（i）疏水相互作用，（ii）核碱基二聚体的形成，以及（iii）磷酸盐/f区元素盐结合。
