Department of Human and Animal Anatomy and Physiology, Herzen State Pedagogical University of Russia, St. Petersburg, Russia.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):1-5. doi: 10.1186/2047-783x-14-s4-1.
It had been hypothesized that the regions of prefrontal cortex which are involved in respiratory control can modulate Hering-Breuer reflexes evoked by vagal input from pulmonary stretch receptors. In the present study, experiments were performed on urethane anesthetized spontaneously breathing Wistar rats. The expiratory-promoting reflex was evaluated from changes in expiratory time immediately after airway occlusion at the end of inspiration. The inspiratory-inhibitory reflex was estimated from changes in inspiratory time provoked by airway occlusion at the end of expiration. The results indicate that electrical microstimulation of the responsive sites within the insular cortex significantly weakened both expiratory-promoting and inspiratory-inhibitory reflex. Activation of the infralimbic cortex depressed expiratory-promoting reflex, but inspiratory-inhibitory reflex was enhanced. These results suggest that stimulation of the prefrontal cortex influences vagally mediated control of the respiratory phases timing and several regions of the prefrontal cortex modulate distinct sets of neurons in the network controlling inspiratory and expiratory phases of a breath cycle.
人们假设，参与呼吸控制的前额叶皮层区域可以调节由肺牵张感受器传入的迷走神经输入引起的 Hering-Breuer 反射。在本研究中，对麻醉的自发性呼吸 Wistar 大鼠进行了实验。通过在吸气结束时气道阻塞后呼气时间的变化来评估呼气促进反射。通过在呼气结束时气道阻塞引起的吸气时间的变化来估计吸气抑制反射。结果表明，电微刺激岛叶皮质内的反应部位显著减弱了呼气促进和吸气抑制反射。激活下边缘皮层抑制呼气促进反射，但增强吸气抑制反射。这些结果表明，前额叶皮层的刺激影响迷走神经介导的呼吸时相定时控制，并且前额叶皮层的几个区域调节控制呼吸周期吸气和呼气时相的神经元的不同集合。
