慢性莱姆关节炎患者血清中溶酶体外切糖苷酶的活性

Activity of lysosomal exoglycosidases in the serum of patients with chronic Lyme arthritis.

作者信息

Pancewicz Slawomir A, Wielgat Przemyslaw, Hermanowska-Szpakowicz Teresa, Kondrusik Maciej, Zajkowska Joanna, Grygorczuk Sambor, Popko Janusz, Zwierz Krzysztof

机构信息

Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Zurawia 14, PL-15540 Białystok, Poland.

出版信息

Int J Med Microbiol. 2006 May;296 Suppl 40:280-2. doi: 10.1016/j.ijmm.2006.01.002. Epub 2006 Apr 3.

DOI:10.1016/j.ijmm.2006.01.002

PMID:16584916

Abstract

To examine the role of lysosomal exoglycosidases in the pathogenesis of Lyme arthritis we studied a group of 18 patients aged 18-72 (mean: 46 yr) diagnosed with chronic arthritis in the course of borreliosis. The control group was composed of 20 healthy volunteers (health service employees) aged 25-65 (mean: 45 yr) with no detectable serum anti-Borrelia burgdorferi antibodies. We found that N-acetyl-beta-d-hexosaminidase (HEX) was significantly increased and beta-galactosidase and alpha-mannosidase also showed an increase in Lyme arthritis patients compared to healthy persons and normalised after treatment with doxycycline. Our results suggest that HEX is a sensitive enzymatic marker of Lyme arthritis and it may be used to monitor the course of the disease and the efficiency of treatment.

摘要

为研究溶酶体外切糖苷酶在莱姆关节炎发病机制中的作用，我们对一组18例年龄在18 - 72岁（平均46岁）、诊断为疏螺旋体病所致慢性关节炎的患者进行了研究。对照组由20名年龄在25 - 65岁（平均45岁）、血清中未检测到抗伯氏疏螺旋体抗体的健康志愿者（卫生服务机构工作人员）组成。我们发现，与健康人相比，莱姆关节炎患者的N - 乙酰 - β - D - 己糖胺酶（HEX）显著升高，β - 半乳糖苷酶和α - 甘露糖苷酶也有所增加，且在接受强力霉素治疗后恢复正常。我们的结果表明，HEX是莱姆关节炎的一个敏感酶标志物，可用于监测疾病进程和治疗效果。